Effect of ginseng saponins on cholesterol metabolism. III. Effect of ginsenoside-Rb1 on cholesterol synthesis in rats fed on high-fat diet.
- 1 January 1978
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 26 (9) , 2844-2849
- https://doi.org/10.1248/cpb.26.2844
Abstract
Rats fed on high-fat diet showed a higher level of cholesterol in liver and a lower incorporation of 14C-acetate into liver cholesterol. The activity of HMG-CoA reductase, which is a key enzyme in cholesterol biosynthesis, was repressed in those rats. Ginsenoside-Rb1 purified from Ginseng (the root of Panax ginseng C.A. MEYER) has been found to reverse such effect of high-fat diet when administered on earlier days of feeding.Keywords
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