Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes
Top Cited Papers
- 26 August 2005
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 38,p. 4764-4776
- https://doi.org/10.1039/b508531b
Abstract
Our work has shown that certain ruthenium(II) arene complexes exhibit promising anticancer activity in vitro and in vivo. The complexes are stable and water-soluble, and their frameworks provide considerable scope for optimising the design, both in terms of their biological activity and for minimising side-effects by variations in the arene and the other coordinated ligands. Initial studies on amino acids and nucleotides suggest that kinetic and thermodynamic control over a wide spectrum of reactions of Ru(II) arene complexes with biomolecules can be achieved. These Ru(II) arene complexes appear to have an altered profile of biological activity in comparison with metal-based anticancer complexes currently in clinical use or on clinical trial.Keywords
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