EFFECT OF LUNG-VOLUME ON VENTILATORY RESPONSE TO CO2 DURING RESISTIVE LOADING IN NORMAL SUBJECTS
- 1 January 1976
- journal article
- research article
- Published by Elsevier
- Vol. 114 (4) , 761-766
- https://doi.org/10.1164/arrd.1976.114.4.761
Abstract
The ventilatory response to CO2 during resistive loading was determined in normal subjects when the end-expiratory level was allowed to increase and when it was restored to that present in the unloaded state. Restoration of the end-expiratory level to that seen in the unloaded state, during the resistive loading, resulted in an increase in ventilatory response to CO2. The mechanism by which increase in lung volume affect the ventilatory response to CO2 is unknown; multiple factors are likely to be involved. An increase in end-expiratory level may play a major role in limiting the ventilatory response to CO2 during resistive loading and may also be an important factor in the reduced ventilatory response to CO2 that is seen clinically when there is obstruction to air flow.This publication has 17 references indexed in Scilit:
- THE OXYGEN CONSUMPTION AND EFFICIENCY OF THE RESPIRATORY MUSCLES IN HEALTH AND EMPHYSEMA*Journal of Clinical Investigation, 1959
- Effects of Graded Resistance to Tracheal Air Flow in ManJournal of Applied Physiology, 1957
- THE EFFECT OF OBSTRUCTION TO BREATHING ON THE VENTILATORY RESPONSE TO CO21Journal of Clinical Investigation, 1956
- ANALYSIS OF THE RESPIRATORY RESPONSE TO CARBON DIOXIDE INHALATION IN VARYING CLINICAL STATES OF HYPERCAPNIA, ANOXIA, AND ACID-BASE DERANGEMENTJournal of Clinical Investigation, 1955
- THE RESPIRATORY RESPONSE TO CO2 IN EMPHYSEMA1954
- Reflex Respiratory Stimulation by Chest Compression in the DogAmerican Journal of Physiology-Legacy Content, 1952
- THE RESPIRATORY RESPONSE TO CARBON DIOXIDE AND ANOXIA IN EMPHYSEMA1949
- EXCITATION AND INHIBITION OF PHRENIC MOTONEURONES BY INFLATION OF THE LUNGSAmerican Journal of Physiology-Legacy Content, 1946
- Afferent impulses in the vagus and their effect on respirationThe Journal of Physiology, 1933
- The vagus influences giving rise to the phenomena accompanying expansion and collapse of the lungsThe Journal of Physiology, 1932