Effect of Verapamil on T-Lymphocyte Activation in Vitro

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Abstract
Verapamil, a Ca-inhibitory drug [used to treat cardiovascular disease], inhibited human T-lymphocyte proliferation in mixed lymphocyte culture and the proliferative response to phytohemagglutinin and mumps antigen. It also inhibited production of interleukin 2 (IL-2). To exert inhibition, verapamil had to be added early in the culture period. Verapamil also had a relatively small inhibitory effect on IL-2-dependent growth. The effects were clearly seen only at concentrations exceeding the therapeutic serum level of verapamil.