No one is naive: the significance of heterologous T-cell immunity
Top Cited Papers
- 1 June 2002
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 2 (6) , 417-426
- https://doi.org/10.1038/nri820
Abstract
Memory T cells that are specific for one virus can become activated during infection with an unrelated heterologous virus, and might have roles in protective immunity and immunopathology. The course of each infection is influenced by the T-cell memory pool that has been laid down by a host's history of previous infections, and with each successive infection, T-cell memory to previously encountered agents is modified. Here, we discuss evidence from studies in mice and humans that shows the importance of this phenomenon in determining the outcome of infection.Keywords
This publication has 97 references indexed in Scilit:
- Relative Dominance of Epitope-Specific Cytotoxic T-Lymphocyte Responses in Human Immunodeficiency Virus Type 1-Infected Persons with Shared HLA AllelesJournal of Virology, 2001
- Control of Homeostasis of CD8 + Memory T Cells by Opposing CytokinesScience, 2000
- Molecular Mimicry by Herpes Simplex Virus-Type 1: Autoimmune Disease After Viral InfectionScience, 1998
- Infection of Mice with Mycobacterium bovis–Bacillus Calmette-Guérin (BCG) Suppresses Allergen-induced Airway EosinophiliaThe Journal of Experimental Medicine, 1998
- Cross‐reactive memory T cells for Epstein‐Barr virus augment the alloresponse to common human leukocyte antigens: degenerate recognition of major histocompatibility complex‐bound peptide by T cells and its role in alloreactivityEuropean Journal of Immunology, 1997
- Lymphocyte life-span and memoryScience, 1994
- T-cell memory: new perspectivesImmunology Today, 1993
- Influenza basic polymerase 2 peptides are recognized by influenza nucleoprotein-specific cytotoxic T lymphocytesMolecular Immunology, 1992
- Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC moleculesNature, 1991
- Recognition of disparate HA and NS1 peptides by an H-2Kd-restricted, influenza specific CTL cloneMolecular Immunology, 1991