Kinetics of Virus-Specific CD8+T Cells and the Control of Human Immunodeficiency Virus Infection
Open Access
- 15 September 2004
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 78 (18) , 10096-10103
- https://doi.org/10.1128/jvi.78.18.10096-10103.2004
Abstract
Several primate models indicate that cytotoxic T lymphocyte-inducing vaccines may be unable to prevent human immunodeficiency virus infection but may have a long-term benefit in controlling viral replication and delaying disease progression. Here we show that analysis of the kinetics of antigen-specific CD8+ T-cell expansion suggests a delay in activation following infection that allows unimpeded early viral replication. Viral kinetics do not differ between controls and vaccinees during this delay phase. An increase in virus-specific CD8+ T-cell numbers around day 10 postinfection coincides with a slowing in viral replication in vaccinees and reduces peak viral loads by around 1 log. However, this response is too little too late to prevent establishment of persistent infection.Keywords
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