Reduced drug accumulation as the mechanism of extreme clinical resistance to methotrexate in the human T-cell leukemia xenograft, LALW-2
Open Access
- 1 September 1991
- Vol. 68 (5) , 981-987
- https://doi.org/10.1002/1097-0142(19910901)68:5<981::aid-cncr2820680512>3.0.co;2-w
Abstract
No abstract availableKeywords
This publication has 21 references indexed in Scilit:
- Therapy-induced drug resistance in a human leukemia line (LALW-2)Cancer, 1989
- Complementation of a methotrexate uptake defect in Chinese hamster ovary cells by DNA-mediated gene transfer.Molecular and Cellular Biology, 1989
- Cytologic evidence for gene amplification in methotrexate-resistant cells obtained from a patient with ovarian adenocarcinoma.Journal of Clinical Oncology, 1984
- Gene amplification in a leukemic patient treated with methotrexate.Journal of Clinical Oncology, 1984
- Resistance to methotrexate due to gene amplification in a patient with acute leukemia.Journal of Clinical Oncology, 1984
- Experimental SettingPublished by Springer Nature ,1984
- Folate AntagonistsPublished by Springer Nature ,1984
- Unstable Methotrexate Resistance in Human Small-Cell Carcinoma Associated with Double Minute ChromosomesNew England Journal of Medicine, 1983
- Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.Proceedings of the National Academy of Sciences, 1979
- Changes of molecular properties associated with the development of resistance against methotrexate in human lymphoblastoid cellsPublished by Elsevier ,1975