Synthesis and properties of dermorphin and an analog of β‐endorphin containing the dermorphin sequence
- 1 March 1983
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 21 (3) , 219-222
- https://doi.org/10.1111/j.1399-3011.1983.tb03097.x
Abstract
Dermorphin (I) and [D‐Ala2, Phe3, Gly4, Tyr5, Pro6]‐βc‐EP (II) have been synthesized by the solid‐phase method (β‐EP, camel β‐endorphin). Positions I through 7 of II correspond to the sequence of I. Relative potencies of synthetic peptides in the mouse tail‐flick test for analgesia by the intracerebroventricular route were: human β‐endorphin, 100; camel β‐endorphin, 164; I, 450; II, 440. The dermorphin was about 670 times more potent than morphine in the assay. Peptide II represents a rare instance where the enkephalin moiety of β‐endorphin has been altered to produce a more potent analgesic.Keywords
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