Penicillins and cephalosporins
- 1 February 1987
- journal article
- review article
- Published by Springer Nature in International Journal of Clinical Pharmacy
- Vol. 9 (1) , 1-23
- https://doi.org/10.1007/bf01956487
Abstract
Penicillins and cephalosporins belong to the most prescribed antibiotics. Despite the relatively extended knowledge of these drugs, the qualitative and quantitative analysis of the compounds still gives rise to many problems. These difficulties are due to the chemical instability of the common Β-lactam nucleus, the minor differences in chemical structures between the analogues, and the complex and relatively fast degradation of the compounds in aqueous solutions. In this review a compilation of the physicochemical properties, the degradation routes and methods for analysis of these substances in biological and other matrices is presented.Keywords
This publication has 188 references indexed in Scilit:
- Analysis for penicillins and cefoperazone by HPLC—photolysis—electrochemical detection (HPLC—hv—EC)Journal of Pharmaceutical and Biomedical Analysis, 1986
- Rapid microbiological pH assay for the determination of cephradine in pharmaceutical formulations and biological fluidsJournal of Pharmaceutical and Biomedical Analysis, 1985
- Visible spectrophotometric determination of cephalosporins and penicillins by indophenol derivatization with and without alkaline degradation to ammoniaJournal of Pharmaceutical and Biomedical Analysis, 1985
- A sensitive enzymic assay for benzylpenicillinJournal of Applied Bacteriology, 1985
- Physicochemical properties of amphoteric .BETA.-lactam antibiotics. IV. First- and second-order degradations of cefaclor and cefatrizine in aqueous solution and kinetic interpretation of the intestinal absorption and degradation of the concentrated antibiotics.CHEMICAL & PHARMACEUTICAL BULLETIN, 1985
- 3-Substituent effect and 3-methylene substituent effect on the structure-reactivity relationship of 7.beta.-(acylamino)-3-cephem-4-carboxylic acid derivatives studied by carbon-13 and IR spectroscopyJournal of Medicinal Chemistry, 1984
- Gamma-radiolysis of sodium ampicillin and its estersThe International Journal of Applied Radiation and Isotopes, 1984
- The interaction between water and cephalexin in the crystalline and noncrystalline states.CHEMICAL & PHARMACEUTICAL BULLETIN, 1984
- Kinetics and mechanism of the degradation and epimerization of sodium cefsulodin in aqueous solution.CHEMICAL & PHARMACEUTICAL BULLETIN, 1984
- Photometric extraction method for determination of cephalexinMicrochimica Acta, 1976