Effects of Reserpine and Chlorpromazine in Prevention of Cerebral Edema and Reversible Cell Damage.

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Abstract
In one group of mice, serotonin and, as control, equal amounts of physiological salt solution were injected into one cerebral hemisphere. This procedure was immediately followed by intravenous injection of Evan''s blue. A second and third group of mice were treated identically following premedication with reserpine or chlorpromazine. In comparing the results by examination of the brains, it was revealed that serotonin induced cerebral edema, whereas the saline controls did not. Reserpine and chlorpromazine, in relatively low dosage, prevented such damage. Lightly anesthetized dogs receiving serotonin injections (3 mg/kg or 0.003 ng) into the internal carotid artery, immediately responded with flaccid hemiplegia (high dose) and spastic hemiplegia (low dose). Reserpine premedication prevented all neurological symptoms, whereas pretreatment with chlorpromazine did not alter the spastic response, but potentiated the depressant effects of serotonin.

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