A Closed Inhalation System for Pharmacokinetic and Metabolism Studies of Volatile Compounds with Small Laboratory Animals
- 1 January 1978
- book chapter
- Published by Springer Nature
- No. 1,p. 373-375
- https://doi.org/10.1007/978-3-642-66896-8_82
Abstract
In the inhalation system described an animal can be kept in the same atmosphere of a 2-liter desiccator for up to 24 h. The expired carbon dioxide is adsorbed with soda lime and the resulting reduced pressure is balanced by a supply of oxygen also used for the inflow of the chemical to be investigated. Urine and faeces can be collected separately and the system allows a periodical control of the concentration of the chemical by sampling the air with needle and syringe.Keywords
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