In Vitro and In Vivo Properties of Antimacrophage Sera

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Abstract
Summary: Rabbit anti-mouse macrophage sera (AMS) were used to study in vitro and in vivo responses of mouse macrophages. AMS treatment of macrophages in vitro reduced their adherence to plastic dishes and interfered with their capacity to phagocytose zymosan particles. Clearance of colloidal carbon from peripheral blood of mice was reduced by intraperitoneal and intravenous inoculation of AMS. Pretreatment of mice with AMS hastened morbidity and mortality following infection with vesicular stomatitis virus; the earlier signs of infection were associated with more rapid appearance of high titers of virus in brain tissue.

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