Partition coefficients of salicylic acid between water and the micelles of some non-ionic surfactants
- 1 March 1972
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 24 (3) , 211-214
- https://doi.org/10.1111/j.2042-7158.1972.tb08966.x
Abstract
Partition coefficients of ionized and unionized salicylic acid molecules between water and the micelles of several non-ionic surfactants have been determined. Those of unionized molecules decreased with decreasing length of the surfactant alkyl chain and with increasing length of the surfactant polyoxyethylene chain. Ionized salicylic acid partitioned to a significant extent only into those surfactants having more than approximately 44 oxyethylene units in their hydrophile. The findings are discussed in terms of their biopharmaceutical significance.Keywords
This publication has 2 references indexed in Scilit:
- Mechanisms of Surfactant Effects on Drug AbsorptionJournal of Pharmaceutical Sciences, 1970
- Nonionic surface-active compounds IV. Micelle formation by polyoxyethylene alkanols and alkyl phenols in aqueous solutionJournal of Colloid Science, 1961