DEFECT IN THE GENERATION OF CYTO-TOXIC T-CELLS IN LEPROMATOUS LEPROSY

  • 1 January 1982
    • journal article
    • research article
    • Vol. 48  (3) , 633-640
Abstract
Cytotoxic T cells are consistently produced in normal individuals after in vitro stimulation by a pool of mitomycin-treated normal lymphocytes. Patients suffering from lepromatous leprosy (LL), presenting with large amounts of Mycobacterium leprae and without a history of erythema nodosum leprosum (ENL), are unable to generate such cytotoxic T cells, while lepromatous patients with ENL which, in the present study were all deprived of M. leprae, react normally.