Chronic lathyrism and atheromatosis in the rat
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Virchows Archiv
- Vol. 380 (2) , 107-117
- https://doi.org/10.1007/bf00430617
Abstract
Temporary chronic administration of Beta-amino-propionitrile (B.A.P.N.) produced morphological and biochemical changes of the aortic wall of rat as well as abnormalities of the plasma lipid levels. A hyperlipidic diet resulted in the blood plasma lipid abnormalities as B.A.P.N. intoxication. Nine weeks of B.A.P.N. followed by 42 weeks of a hyperlipidic diet increased the aortic cholesterol level and induced an atheroma. The diet alone produced only an endothelial lipid overload. The structure of arterial wall played the decisive role in atherogenesis.This publication has 18 references indexed in Scilit:
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