THE EFFECT OF INTRAVENOUS INJECTION OF CALCIUM LACTATE UPON GASTRIC SECRETION

Publisher Website
Google Scholar
Abstract
Five gastric pouch dogs were prepared. The normal rates of gastric secretion and the physiological level of blood Ca were determined for each animal. One-tenth gm. Ca lactate per kgm. of body weight (13 mgm. Ca per kgm.) was injected intravenously and the effect of this dose upon the level of blood Ca and on the rate of secretion of gastric juice studied separately. In every case a marked hypercalcemia unaccompanied by obvious untoward effects was produced. This effect was transient, lasting from 3 to 6 hrs. All variations in gastric secretion rate accompanying the change in level of blood Ca were considered to be within normal physiological limits. The final control response to histamine showed that in every case the experimental conditions were satisfactory for demonstrating the se- cretion of gastric juice in response to an adequate stimulus. The hypercalcemia produced in these experiments was not an adequate stimulus. This study does not confirm the work of Sereghy and von Gyurkovich.

This publication has 1 reference indexed in Scilit: