EFFECT OF AMINOPHYLLINE ON AMPHOTERICIN-B NEPHROTOXICITY IN THE DOG

  • 1 January 1983
    • journal article
    • research article
    • Vol. 224  (3) , 609-613
Abstract
The polyene antibiotic, amphotericin B [an antifungal agent] causes an acute reduction in renal blood flow and glomerular filtration rate. The hypothesis that the renal vascular response to amphotericin B can be blocked by aminophylline was evaluated. The effect of aminophylline on the renal response to amphotericin B in Na-depleted dogs was examined. In dogs not treated with aminophylline, amphotericin B (0.5 mg/kg infused i.v. over 20 min) significantly reduced renal blood flow and glomerular filtration by 49.9 .+-. 12.6 ml/min (.hivin.X .+-. SEM [standard error of the mean]) and 23.4 .+-. 2.4 ml/min, respectively, at 140 min after the amphotericin B infusion. In dogs treated with an intrarenal aminophylline infusion (5 mg/min), the renal blood flow and glomerular filtration rate response to ampotericin B did not differ from that of amphotericin B vehicle. Aminophylline evidently inhibits the renal response to amphotericin B. The possible clinical relevance of these observations are discussed.

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