Elevated Angiotensin I-Converting Enzyme in Histiocytic Medullary Reticulosis

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Abstract
To the Editor: Increased urinary lysozyme concentrations in histiocytic medullary reticulosis have been reported.1 This rare disease is considered to be a neoplasm of true histiocytes and to be connected with fever, lymphadenopathy, and hepatosplenic infiltration. Benign as well as malignant proliferation of cells of the monocyte–macrophage series is accompanied by raised serum and urinary levels of lysozyme,2 which is produced by these cells.Increased activity of serum angiotensin I-converting enzyme has been reported in sarcoidosis3 and in Gaucher's disease4 — a lipid-storage disease connected with histiocyte proliferation. Histiocytes and macrophages are believed to produce this enzyme under certain conditions, . . .