Glycosaminoglycan Synthesis in Endotoxin-Induced Lung Injury

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Abstract
Changes in a connective tissue compartment, glycosaminoglycans, during the acute phase of endotoxin-induced lung injury were studied. I.v. administration of a single dose of endotoxin [Escherichia coli] in rats resulted in an increase in the total synthesis of glycosaminoglycans by the pulmonary parenchyma. There was a significant increase in the proportion of dermatan sulfate synthesized during the first 48 h and a concomitant decrease in heparin/heparan sulfate synthesis. At 48 h the increased synthesis of dermatan sulfate had reached 7.3 times control values and began to decline; the synthesis of chondroitin-4-sulfate rose from 4.1 to 10.7 times control values between 48-72 h. Analysis of the rates of synthesis revealed that the total amount of heparin/heparan sulfate remained constant while the synthesis of chondroitin-6-sulfate increased proportionally to the overall synthesis of glycosaminoglycans. Thus, dramatic changes in glycosaminoglycan synthesis are an integral part of endotoxin lung injury.

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