Nucleic Acid Base Pair Dynamics: The Impact of Sequence and Structure Using Free-Energy Calculations
- 1 April 2003
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 125 (17) , 4998-4999
- https://doi.org/10.1021/ja034095r
Abstract
Molecular dynamics free-energy calculations of base pair opening within double helical DNA and RNA are used to explain why A-tracts (oligo-adenine repeats) greatly increase the lifetimes of AT base pairs, whereas the structural and the chemical changes involved in passing from B-DNA to A-RNA have comparatively small effects.Keywords
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