Hypoglycemic depression of RES function

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Abstract
The intravascular removal rates of colloidal C and biologically active [Salmonella enteritidis] endotoxin by the RES were evaluated as a function of blood-glucose levels [in rats]. There was a significant negative correlation of C clearance half time on blood glucose in saline-treated and insulin-treated rats. Insulin hypoglycemia depressed RES C clearance with the maximal effect occurring at blood glucose values < 30 mg/dl. Insulin hypoglycemia also severely impaired the intravascular removal of endotoxin as evaluated by lethality bioassay in Pb-sensitized rats. Blood glucose may modulate RES phagocytic function and the hypoglycemia of endotoxin shock may augment the shock state due to impairment of RES host defense clearance functions.

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