Prodrugs as drug delivery systems. 43. O-acyloxymethyl salicylamide N-Mannich bases as double prodrug forms for amines
- 2 March 1986
- journal article
- research article
- Published by Elsevier in International Journal of Pharmaceutics
- Vol. 29 (1) , 19-28
- https://doi.org/10.1016/0378-5173(86)90195-x
Abstract
No abstract availableKeywords
This publication has 15 references indexed in Scilit:
- Prodrugs of 5-fluorouracil. IV. Hydrolysis kinetics, bioactivation and physicochemical properties of various N-acyloxymethyl derivatives of 5-fluorouracilInternational Journal of Pharmaceutics, 1985
- A convenient synthesis of (acyloxy)alkyl .alpha.-ethers of phenolsThe Journal of Organic Chemistry, 1983
- O-acylsalicylamides as possible prodrugs for salicylamide I. Kinetics and mechanisms of their degradation and reaction with enzymes and sodium bisulfiteInternational Journal of Pharmaceutics, 1983
- Hydrolysis of N-Mannich bases and its consequences for the biological testing of such agentsInternational Journal of Pharmaceutics, 1981
- Pro-drugs as drug delivery systems XIX. Bioreversiblf derivatization of aromatic amines by formation of N-Mannich bases with succinimideInternational Journal of Pharmaceutics, 1981
- Pro-drugs as drug delivery systems XV. Bioreversible derivatization of phenytoin, acetazolamide, chlorzoxazone and various other NH-acidic compounds by N-aminomethylation to effect enhanced dissolution ratesInternational Journal of Pharmaceutics, 1980
- Prodrugs as Drug Delivery Systems IV: N-mannich bases as Potential Novel Prodrugs for Amides, Ureides, Amines, and Other NH-acidic CompoundsJournal of Pharmaceutical Sciences, 1980
- Acylal hydrolysis. Hydrolysis of 3-(p-nitrophenoxy)phthalide, .alpha.-acetoxybenzyl p-nitrophenyl ether, and 3-(Para-substituted thiophenyl)phthalidesJournal of the American Chemical Society, 1974
- Intestinal Drug Absorption and Metabolism I: Comparison of Methods and Models to Study Physiological Factors of In Vitro and In Vivo Intestinal AbsorptionJournal of Pharmaceutical Sciences, 1970
- Intramolecular Participation of the Amide Group in Ester Hydrolysis1The Journal of Organic Chemistry, 1964