Tissue Engineered Growth of New Cartilage in the Shape of a Human Ear Using Synthetic Polymers Seeded with Chondrocytes
- 1 January 1991
- journal article
- Published by Springer Nature in MRS Proceedings
Abstract
This report concerns the tissue-engineered growth of new cartilage in the shape of a human ear. Using synthetic biodegradable polyesters, a porous, three dimensional device in the shape of a human ear was fabricated. The polymer matrices were seeded with living chondrocytes isolated from a freshly sacrificed calf shoulder and implanted subcutaneously on the dorsum of athymic rats. This resulted in the formation of new cartilage in the shape of a human ear of approximately the same dimensions as the original implants. Histological analysis revealed the presence of mature cartilage in all specimens.Keywords
This publication has 7 references indexed in Scilit:
- Tissue Engineering by Cell Transplantation Using Degradable Polymer SubstratesJournal of Biomechanical Engineering, 1991
- Absorbable Suture Materials: Preparation and PropertiesJournal of Macromolecular Science, Part C: Polymer Reviews, 1988
- Resorbable materials of poly(L-lactide)Colloid and Polymer Science, 1983
- Biodegradation of surgical polymersJournal of Materials Science, 1982
- The effect of pH on the in vitro degradation of poly(glycolide lactide) copolymer absorbable suturesJournal of Biomedical Materials Research, 1982
- Biodegradable polymers for use in surgery—polyglycolic/poly(actic acid) homo- and copolymers: 1Polymer, 1979
- [50] Large-scale preparation of chondrocytesPublished by Elsevier ,1979