Synthesis of the amino-terminal decapeptide of human calcitonin, in which the disulfide bond is replaced by a thioether group
- 1 January 1980
- journal article
- Published by Institute of Organic Chemistry & Biochemistry in Collection of Czechoslovak Chemical Communications
- Vol. 45 (4) , 1305-1314
- https://doi.org/10.1135/cccc19801305
Abstract
A fully protected amino-terminal decapeptide Ib with the sequence of human calcitonin, in which the S-S bridge was replaced by the S-CH2 group (a so-called 7-carba-analogue), was synthetized mainly by the stepwise method. The cyclization of the linear decapeptide was performed by means of active ester.Keywords
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