Combined Action of Phthalocyanine Photosensitization and Gamma-radiation on Mammalian Cells
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 54 (1) , 21-30
- https://doi.org/10.1080/09553008814551471
Abstract
The response of Chinese hamster cells and human lymphocytes to the combined action of photosensitization by chloroaluminium phthalocyanine tetrasulfonate and gamma-radiation was studied using colony-forming ability and [3H]thymidine incorporation following mitogenic stimulation respectively, as endpoints. The action of both treatments was usually additive regardless of the sequence of application. However, in human lymphocytes irradiated at low temperature, the photosensitization interacted synergistically with the sub-sequent ionizing radiation; in this experiment the initial photosensitization reduced the yield of micronuclei produced by gamma-radiation.This publication has 24 references indexed in Scilit:
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