Neoadjuvant cis-DDP in esophageal cancers: An experience at a regional cancer centre, India

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Abstract
We are analysing the results of 80 patients who underwent surgery during 1983‐84 for esophageal cancer. Forty patients who received pre‐operative single agent Cis‐DDP were grouped under “A” and 40 patients who went for surgery directly were grouped under “B.” Twenty‐two patients (55%) of Group A showed tumor necrosis. Both groups underwent resection and hand‐sewn anastamosis of the esophagus. There were 10 post‐operative deaths among 80 resected cases, 9 of them being from anastomatic leak. Cis‐DDP has induced negligible side effects. A comparatively high survival rate during early years in patients who responded to Cis‐DDP suggests that neoadjuvant chemotherapy might be of value.