Effect of hypophysectomy on hypothalamic somatostatin content in rats.
- 1 January 1976
- journal article
- research article
- Published by Japan Endocrine Society in Endocrinologia Japonica
- Vol. 23 (5) , 439-442
- https://doi.org/10.1507/endocrj1954.23.439
Abstract
The effect of hypophysectomy on the hypothalamic somatostatin content was examined in rats. Somatostatin content in the acid extract of the pituitary stalk and the median eminence tissue (SME) was measured by specific radioimmunoassay. In young male rats, mean somatostatin content in SME was 63.9 .+-. 5.0 ng. Two wk after hypophysectomy, it was reduced significantly to 34.4 .+-. 3.3 ng. The elimination of feedback actions of GH [growth hormone] and/or TSH [thyrotropin] on the hypothalamus decreased the synthesis and/or the release of somatostatin. The possibility that structural changes in the pituitary stalk and the median eminence tissue ensued after hypophysectomy depleted somatostatin cannot be ruled out.This publication has 1 reference indexed in Scilit:
- THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITYBiochemical Journal, 1963