The binding of recombinant human relaxin to human spermatozoa
- 1 January 1995
- journal article
- research article
- Published by Taylor & Francis in Endocrine Research
- Vol. 21 (3) , 697-707
- https://doi.org/10.1080/07435809509030484
Abstract
Porcine relaxin has been reported to stimulate various human sperm functions. In this paper we report that human recombinant relaxin binds to human sperm with a high affinity (Kd = 6.5 X 10−10). The bound 125I- relaxin was not displaced by insulin, or human chorionic gonadotropin, however, it was displaced by unlabeled relaxin. In sperm function studies, recombinant human relaxin stimulated sperm motility, zona-free hamster egg penetration, and the acrosome reaction.Keywords
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