Genomic structure and functional characterization of the human ADAM10 promoter

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Abstract
SPECIFIC AIMSIncreasing the expression of ADAM10 is a potential strategy to prevent Alzheimer disease. A specific aim was to identify the promoter of the ADAM10 gene and to characterize elements essential for strong promoter activity. We looked for an inducer of ADAM10 expression, analyzed SNPs located in the human ADAM10 promoter region, and describe the genomic organization of the human ADAM10 gene.PRINCIPAL FINDINGS1. The genomic organization and the promoter of human and mouse ADAM10 genes are highly conservedBy comparing ADAM10 cDNA sequences with genomic databases, we have delineated the genomic organization of human and mouse ADAM10 genes. Both gene loci share remarkable similarities: they comprise ∼160 kbp and are composed of 16 exons. With exception of exon 16, which is 764 bp in length, all other exons of the human ADAM10 gene are relatively small, ranging from 93 to 499 bp. The intron sizes range between 482 and 35262 bp with the largest introns located primarily at the 5′-end of the human gene...
Funding Information
  • Deutsche Forschungsgemeinschaft