Metastatic Calcification Induced by Hytakerol in Rats Infected with Plasmodium berghei

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Abstract
High doses of hytakerol (dihydrotachysterol) produced in control rats and in rats infected with Plasmodium berghei metastatic calcifications in various organs. In general the infected animals showed a lower incidence of calcification than the controls, this quantitative difference being especially pronounced in respect to the coronaries and the great heart vessels. In one organ only, viz., the stomach, a qualitative difference was observed. The majority of infected animals showed a mosaic-like pattern of calcification in the interglandular tissue while in most control animals the calcium was distributed in an irregular fashion throughout the mucosa without leading to the mosaic-like pattern.

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