HYPERLIPOPROTEINEMIA IN NEWBORN INFANTS

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Abstract
As part of a screening study for the detection of hyperlipoproteinemia in 10,000 newborns, cord serum lipids and lipoproteins were measured in detail in 1025 infants. Elevated cord serum VLDL-LDL[Very low density lipoprotein-low density lipoprotein]-cholesterol could easily be identified by a rapid tubidimetric estimation of cord serum VLDL-LDL. Cord serum VLDL-LDL-cholesterol was significantly higher than normal in premature, asphyxiated and betamethasone-phenobarbital-ritodrine treated infants. Other obstetric complications were not associated with hyperlipoproteinemia. All 2050 parents had their serum cholesterol determined. Three parents had familial hypercholesterolemia (FH). One child also had FH, though her cord serum total cholesterol and VLDL-LDL-cholesterol were normal. The 2 other children of the 3 FH parents had normal lipids and lipoproteins at birth and follow-up.