Comparison of Duration of Action of Progesterone and 17- -Hydroxyprogesterone-17-n-Caproate

Publisher Website
Google Scholar
Abstract
The progestational properties of 17-[alpha]-hydroxyprogesterone- 17-n-caproate (HPC) were compared with progesterone in rabbits using ethyl lactate-castor oil and benzyl benzoate-sesame oil as vehicles. A single injection of HPC in ethyl lactate-castor oil caused a peak response at 7 days, whereas peak responses were noted at 4 days with HPC in benzyl benzoate-sesame oil. Progestational proliferation was observed up to 20 days following the single injection of HPC in benzyl benzoate-sesame oil, whereas the luteoid action of progesterone was unobservable at 8 days. 17-[alpha]-hydroxyprogesterone per se proved about l/100th as active as progesterone in studies of shorter duration.

This publication has 1 reference indexed in Scilit: