Production of an Antibody Deficiency Syndrome in Rabbits by Neonatal Removal of Organized Intestinal Lymphoid Tissues

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Abstract
Neonatal removal of the sacculus rotundus, appendix and Peyer''s patches which significantly reduces the levels of circulating immunoglobulins, ability to produce antibody to 3 of 4 antigens and total numbers of circulating lymphocytes, results in a pronounced survival disadvantage. These operations do not affect development of the capacity to reject skin homografts or to express the delayed type of hypersensitivity. Neonatal appendectomy alone results in decreased numbers of circulating lymphocytes, depression of antibody response to 1 of 4 antigens and reduced levels of immunoglobulins. Removal of the Peyer''s patch-type of tissue promotes the development of Coombs positively of the red blood cells which is attributable to the presence of both IgG [immunoglobin G] and B 1C globulin on the red cell surface. The Peyer''s patch type of lymphoid tissue in the rabbit may represent a functional equivalent of the bursa of Fabricius in the chicken.

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