B-Cell and T-Cell Markers in Lymphoid Proliferations

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Abstract
The recent discovery of surface markers considered to be specific for human thymus-derived (T) and bone marrow-derived (B) cells has provided new insights into the pathogenesis of immunoproliferative and immunodeficiency diseases.1 However, the diagnostic value of these markers needs critical evaluation, and the interpretation of investigative results requires much caution.The spontaneous formation of rosettes with sheep erythrocytes appears to be a specific property of T lymphocytes. However, quantitation of rosette-forming T cells is not standardized, and the fundamental nature of the phenomenon is unknown. Most heteroantiserums "specific" for human T or B cells are only relatively specific and are . . .

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