Sodium – lauryl – sulphate – induced cutaneous irritation

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Abstract
Reactivity of white and hispanic skin after exposure to sodium tauryl sulphate (SLS) has been investigated. The tests were performed on the back as follows: untreated skin, skin pre‐treated with short‐term occlusion and delipidized skin. Irritant reactions were induced by applying 0.5% and 2.0% SLS via Finn chamber patch tests and monitored by means of laser Doppler velocimetry (LDV), transepidermal water loss (TEWL) and stratum corneum water content (WC). Higher TEWL, LDV and WC were recorded for 2.0% SLS when compared to 0.5% SLS and baselines. Differences between while and hispanic skin reactivity were recorded. TEWL and WC responses showed a greater sensitivity in hispanics possibly reflecting a different modulation of the water burner function after chemical exposure. On the other hand, the microcirculatory response, as long as detected with LDV, was similar in the 2 groups. Correlations between these data and findings observed in other races are discussed.