CIS-DICHLORODIAMMINEPLATINUM(II) CHEMOTHERAPY IN EXPERIMENTAL MURINE MYELOMA MOPC-104E

  • 1 January 1977
    • journal article
    • research article
    • Vol. 37  (3) , 771-774
Abstract
Data are presented indicating marked antineoplastic activity for cis-dichlorodiammineplatinum(II) in MOPC 104E [mouse] myeloma. One-eighteenth of the dose that produced 100% cures can be combined with noncurative, low doses of cyclophosphamide and 1,3-bis(2-chloroethyl)-1-nitrosourea to produce antineoplastic activity of the same degree as that produced by higher dose regimens which regularly produce cures. Since, in the past, results of therapeutic trials in plasma cell tumors in humans paralleled results in this animal model, clinical trials of cis-dichlorodiammineplatinum in multiple myeloma appear warranted.

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