Intradermal Tests in the Diagnosis of Lymphogranuloma Venereum

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Abstract
Patients (1317) attending a clinic for venereal diseases in the east end of London were subjected to routine intradermal tests with a yolk sac antigen of the virus of lymphogranuloma venereum. Positive tests were found in 206 cases (18.4%). In 23 of these, a diagnosis of lymphogranuloma venereum was confirmed by a strongly positive complement fixation test. A considerably larger number showed complement fixing antibodies in insufficient titer to justify a firm diagnosis of active infection. Only 10 patients were found to have clinical evidence of this disease. The incidence of positive skin tests was 16% in white males, 11% in white females, 50% in Negro males and 36% in Negro females. Most of the Negroes were immigrants from the West Indies. It is concluded that there is an appreciable amount of undiagnosed lymphogranuloma venereum in the population of the east end of London.

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