Comparison of the carcinogenic effectiveness in mouse skin of methyl- and ethylnitrosourea, nitrosourethane and nitrosonitro-guanidine and the effect of deuterium labeling

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Abstract
The carcinogenic activities of a number of directly acting methyiating and ethylating agents have been compared by mouse skin painting in acetone solution. Nitrosomethyl-urethane and nitrosoethylurethane failed to induce tumors after >60 weeks treatment. Nitrosomethylurea was somewhat more effective than Nitrosoethylurea, as measured by the longer latent period of tumor induction by the latter. Nitrosomethylnitroguanidine, by the same measure, was a weaker carcinogen than Nitrosoethy Initroguaninidine at both dose levels used (0.02 M and 0.008 M); the latter compound was the most potent skin carcinogen of those examined. There was no significant difference in carcinogenic effectiveness when the alkyl group of the nitrosoureas or the nitro-nitrosoguanidines contained deuterium instead of hydrogen, which supports the concept that alkylation of cellular macro-molecules by the intact alkyl group is responsible for carcinogenesis by these compounds.

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