Insulin‐like growth factor II stimulates glucose transport in human skeletal muscle
Open Access
- 3 August 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 307 (3) , 379-382
- https://doi.org/10.1016/0014-5793(92)80717-u
Abstract
We investigated the effect of insulin‐like growth factor II (IGF‐II) and insulin‐like growth factor binding protein‐1 (IGFBP‐1) on 3‐O‐methylglucose transport in incubated human skeletal muscle strips. Increasing physiological concentrations of IGF‐II stimulated glucose transport in a dose‐dependent manner. Glucose transport was maximally stimulated in the presence of 100 ng/ml (13.4 nM) of IGF‐II, which corresponded to the effect obtained by 100μU/ml (0.6 nM) of insulin. Exposure of muscle strips to IGFBP‐1 (500 ng/ml) inhibited the maximal effect of IGF‐II on glucose transport by 40%. Thus, it is conceivable that IGF‐II and IGFBP‐I are physiological regulators of the glucose transport process in human skeletal muscle.Keywords
This publication has 29 references indexed in Scilit:
- Insulin-Like Growth Factor Binding Proteins: Structural and Molecular RelationshipsGrowth Factors, 1991
- Exercise‐induced changes in insulin‐like growth factors and their low molecular weight binding protein in healthy subjects and patients with growth hormone deficiencyEuropean Journal of Clinical Investigation, 1990
- Human insulin‐like growth‐factor‐binding proteinEuropean Journal of Biochemistry, 1989
- An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects.Journal of Clinical Investigation, 1988
- Insulin‐like growth factor I binding and receptor kinase in red and white muscleFEBS Letters, 1988
- Short-Term Metabolic Effects of Recombinant Human Insulin-like Growth Factor I in Healthy AdultsNew England Journal of Medicine, 1987
- Effect of Trypsin Treatment of Rat Adipocytes on Biological Effects and Binding of Insulin and Insulin‐Like Growth FactorsEuropean Journal of Biochemistry, 1981
- Insulin‐Like Growth Factors I and II: Some Biological Actions and Receptor Binding Characteristics of Two Purified Constituents of Nonsuppressible Insulin‐Like Activity of Human SerumEuropean Journal of Biochemistry, 1978
- Insulin and nonsuppressible insulin-like activity (NSILA-S) stimulate the same glucose transport system via two separate receptors in rat heartBiochemical and Biophysical Research Communications, 1977
- Stimulation of35S Incorporation into Embryonic Chick Cartilage by Extract from Rat MuscleHormone and Metabolic Research, 1969