Kinetics of Human Antibody Responses to Primary Genital Herpes Simplex Virus Infection

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Abstract
Five patients with primary genital herpes simplex virus (HSV) infection were studied prospectively for the production of serum antibody reactivity as measured by the virus microneutralization test (NT), micro-solid phase radioimmunometric assay (micro-SPRIA) and antibody-dependent cellular-cytotoxic (ADCC) test. ADCC antibody was detected before reactivity measured by either NT or micro-SPRIA in 2 of the 5 patients. A 3rd patient failed to produce neutralizing antibody, specific activity was detected by the other 2 methods. In 2 other patients of good correlation was observed for development of antibody by all 3 methods. There were several discordant results in the kinetics of production of antibody detected by these assays, suggesting that not all individuals produce similar types of antiviral antibody.