Source of Secretion of Milk "Let-Down" Hormone in Domestic Mammals

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Abstract
The neurohypophyses of a series of animals were separated into the median eminence, stalk and posterior lobe. The acetone-dried tissue in each division was extracted and assayed for milk "let-down" hormone content, using lactating sows as assay animals. The median eminence usually contained insufficent hormone to cause milk "let-down." In a few cases some activity was observed. Evidently this hormone is either not secreted in the hypothalamus or, if secreted there, exists in an inactive form which becomes active only as it passes down the stalk into the posterior lobe. Since the posterior lobe contained roughly 10 times the amt. present in the stalk per unit of dry matter, the posterior lobe is probably the source of the milk "let-down" hormone.

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