ADRENAL RESPONSIVENESS IN AGEING BRATTLEBORO RATS WITH HEREDITARY DIABETES INSIPIDUS

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Abstract
Levels of corticosterone were measured in the plasma of male and female Brattleboro rats with hereditary diabetes insipidus (DI) and normal rats of the same strain, both at rest and after 15 min ether stress, on animals between 37 and 138 weeks old. Levels of plasma corticosterone were significantly lower in DI rats at rest compared with the level in heterozygous control rats. In stressed rats there were no significant differences in mean levels of plasma corticosterone between rat genotypes, within sexes. However, in both genotypes the corticosterone levels were significantly higher in females, irrespective of treatment. Although the resting plasma corticosterone levels were drastically depressed in homozygous DI rats, there was no impairment of the response to stress; the adrenal glands of homozygous rats were significantly more responsive to stress than the corresponding heterozygous rats. Adrenal responsiveness was not a satisfactory parameter of ageing in this strain of rat.

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