CITRIC ACID METABOLISM AS INDICATED BY URINARY EXAMINATION

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Abstract
The animal under cumulative citric acid feeding developed a remarkable power of oxidation, as shown by decrease of organic acid excretion and low excretion of citric acid. A pig has a low liability to ketosis. The small amount produced is not sufficient to show a conspicuous decrease in acetone bodies produced because of this increased oxidative power. There is found to be a variable flushing point where the body can not cope with the quantity of acid ingested, causing an increased excretion of citric acid. An inverse relation obtains between total amount of free acid excreted in 24 hrs. and total urine production. Ca excretion in the compensation against excess of citric acid intake appears unimportant. P was found to be unimportant in the increased urine acidity caused by citric acid ingestion. Total organic acid titration shows no direct relation to citric acid or acetone excreted, but does give some indications of the changes of oxidative power of the body.

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