Antibody response to Rocky Mountain spotted fever

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Abstract
Various techniques were compared to determine the most sensitive method for detection of Rocky Mountain spotted fever antibody. A radiometabolic technique for detection of Rocky Mountain spotted fever antibody is also described. In infected [rhesus] monkeys, the fluorescent antibody technique yielded the earliest evidence of seroconversion; with some monkeys the microagglutination procedure was equally effective. The fluorescent antibody and microagglutination measurements showed higher titers than those for complement fixation, Weil-Felix or the radiometabolic techniques.