Synthesis, Transformation Chemistry, and Biological Activity of Guanine Nucleosides and Analoges
- 1 January 1989
- journal article
- plenary lectures
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 8 (5) , 725-741
- https://doi.org/10.1080/07328318908054211
Abstract
Regiospecific (9-) and regioselective (7-) coupling procedures have been developed with easily prepared guanine derivatives. Acyclovir and 9-(D-pentofuranosyl)guanine nucleosides have been prepared without observed formation of 7-isomers. Guanosine has been functionalized and transformed into a variety of base and/or sugar modified analogues. Potent activity against HIV and a hepadnavirus has been found.Keywords
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