Synthesis and Antimicrobial Activity of New 4-(Benzylsulfanyl)pyridine Derivatives
- 1 January 1999
- journal article
- Published by Institute of Organic Chemistry & Biochemistry in Collection of Czechoslovak Chemical Communications
- Vol. 64 (2) , 417-434
- https://doi.org/10.1135/cccc19990417
Abstract
A series of 4-(benzylsulfanyl)pyridine-2-carbonitriles 2 and 4-(benzylsulfanyl)pyridine-2- carbothioamides 3 was synthesized and their antimycobacterial and antifungal activities were tested. The prepared compounds exhibit significant activity both against M. tuberculosis and nontuberculous mycobacteria. The most active compounds show the MICs of 4 μmol/l. The antifungal activities of 2 are very weak, compounds 3 are inactive against all the tested fungi.Keywords
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