ON THE CONFORMATIONAL INSTABILITY OF HUMAN SERUM LOW-DENSITY LIPOPROTEIN: EFFECT OF TEMPERATURE
- 1 January 1969
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 62 (1) , 171-178
- https://doi.org/10.1073/pnas.62.1.171
Abstract
When examined by circular dichroism and ultraviolet spectroscopy, human serum low-density lipoprotein (LDL) and its delipidated product, apo LDL, exhibited reversible thermal changes. The more marked temperature sensitivity of apo LDL as compared to LDL was taken to support a constraining role by lipids on the observed structural instability of the apoprotein.Keywords
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