In vitro activity of linezolid against multiply resistant Gram-positive clinical isolates
Open Access
- 1 January 2001
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 47 (1) , 77-81
- https://doi.org/10.1093/jac/47.1.77
Abstract
The in vitro activity of the oxazolidinone linezolid was compared with the activities of vancomycin and teicoplanin against 450 Gram-positive clinical isolates, including a variety of multiply resistant strains. Linezolid inhibited all microorganisms tested at ≤4 mg/L, including methicillin- and teicoplanin-resistant staphylococci, glycopeptide-resistant enterococci, penicillin- and multiply resistant pneumococci and viridans streptococci, and erythromycin-resistant β-haemolytic streptococci. The MIC90 of linezolid for all isolates was 2 mg/L.Keywords
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