Synthesis of chiral piperazin-2-ones as model peptidomimetics
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 9,p. 1687-1689
- https://doi.org/10.1039/p19890001687
Abstract
The enantiospecific synthesis of (3S,6R)-6-ethoxycarbonyl-3-(p-hydroxybenzyl)piperazin-2-one (1) and (3S)-1-(ethoxycarbonylmethyl)-3-(p-hydroxybenzyl)piperazin-2-one (2) and their enantiomers is described. The chiral C-6 centre of (1) is generated by a regiospecific protonation of the enamide precursor.This publication has 0 references indexed in Scilit: