ISOLATION OF 13 CLONED HYBRID CELL LINES SECRETING MOUSE STRAIN A DERIVED ANTIBODIES WITH SPECIFICITY FOR GROUP-A STREPTOCOCCAL CARBOHYDRATE

  • 1 January 1978
    • journal article
    • research article
    • Vol. C129  (2-3) , 389-400
Abstract
Hybrid cell lines (13) originating from the fusion of a BALB/c myeloma with strain A spleen cells were isolated. Each cell line secreted an antibody with specificity for the carbohydrate of group A streptococci. The cell lines were stable over many in vivo passages in (BALB/c .times. A/J)F1 mice and secreted large amounts of antibodies into the serum and ascitic fluid of their hosts. Seven of the hybrid cell antibodies belonged to the Ig[immunoglobulin]M class, 5 were typed as IgG2a and 1 as an IgA.

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